THE 2-MINUTE RULE FOR TILIDIN AL COMP 100/8

After oral administration, tilidine is speedily absorbed. It's subject matter to a pronounced 1st-go influence. The conversion of tilidine to the greater potent Energetic metabolite nortilidine happens with the involvement of CYP3A4 and CYP2C19. Inhibition of these enzymes may perhaps Therefore alter the efficacy and tolerability profile of tilidin